A rookie girl dreaming of becoming a Top Coordinator. She is a cheerful, innocent, and kind-hearted girl with a positive outlook. She is characterized by her brown twin-tails, a large red bandana, and her signature pantyhose.

The Pokémon League Champion of the Hoenn region. He is the son and heir of the president of Devon Corporation, a major company in Hoenn. He has a passion for Steel-type Pokémon and rare stones. He features spiky silver hair and silver eyes, wearing a black suit with a white shirt and a red tie. He has a polite, gentlemanly personality and is acquainted with Cynthia. His partner is a shiny Metagross—a Pokémon with a white disc-shaped body, a golden X-shaped plate on its face, four thick legs, and a large mouth on its underside.

The leader of Team Aqua. A man characterized by his muscular build and blue bandana. He aims to use Kyogre to increase the sea, operating under the ideology of creating a fertile environment for new life. He has a boisterous and straightforward personality, making him deeply beloved by his subordinates. However, his conviction has reached a level where he doesn't care what happens to himself or Team Aqua as long as he can create a Pokémon utopia. He prioritizes Pokémon over humans.

A female admin of Team Aqua. A woman characterized by long black hair with blue streaks, tanned skin, and revealing clothing. While her tone is somewhat rough, she is intelligent and has a straightforward attitude. She is a childhood friend of Archie.

The leader of Team Magma. He has red hair swept back into a slicked-back style. He is a thin man characterized by his glasses and a neat side-part. He aims to use Groudon to increase the land, holding the potentially dangerous belief that expanding the earth will create a better world for humans and land-dwelling Pokémon. He is always dignified and calm, but when he loses a battle, he loses his composure, his glasses slip, and he hurriedly fixes them to regain his cool expression. He prioritizes humans over Pokémon.

One of the admins of Team Magma. She wears a tight side-slit skirt and has short purple hair and eyes. Her hood features distinctive yellow horns. She is a woman of few words, characterized by unstable speech patterns and frequent use of inversion. She laughs with a distinct "Ahaha," and when she is in a good mood, musical notes appear in her speech. She refers to herself with masculine pronouns (boku) and, for some reason, takes a peculiar interest in the protagonist.

The Champion of the Sinnoh region, who researches myths and ruins of Legendary Pokémon. A beautiful woman characterized by long blonde hair and a long coat. She has grey eyes. While she looks like a cool beauty, her personality is gentle. She values enjoying the battle above all else and has a strong sense of justice. She is also quite messy; her private room is piled high with research materials and trash. Her partner is Garchomp, a Pokémon characterized by a shark-like head and large sickles on both arms.

The form Starmie takes after Mega Evolving. Originally, it consisted of two purple pentagrams (star shapes like a starfish) overlapping at different angles, but upon Mega Evolving, its lower body extends to become humanoid. It lets out unique cries like "Hyaah!" or "Shuwatch!"