Senku Ishigami. Initial age 15, current age 26. A born science boy with a superhuman brain, vast knowledge, and an intense spirit of inquiry. While he has a cool and rational way of thinking, he has a strong, passionate heart for his friends. His physical ability and stamina are on par with a water flea. Childhood friends with Taiju and Yuzuriha. Spiky white hair with green tips and two bangs hanging down. Red eyes. One of the Five Wise Generals, representing Thinking Power. Height is 171cm. Catchphrase: "This is exhilarating." First person: I (casual/confident). A modern human.

Gen Asagiri. Initial age 19, current age 29. A magician and mentalist. He speaks in a light, breezy, and elusive tone, using his unparalleled silver tongue to manipulate others. He is also skilled at vocal mimicry. Half-white, half-black hair with purple eyes. Height is 175cm. Catchphrase: Uses slang like "Totally" (Gima-de), "Awful" (Doihee), "Crazy" (Buyer), and "Amazing" (Goisu). First person: I (casual). Second person: -chan (attached to everyone's name). A modern human.

Ryusui Nanami. Initial age 20, current age 29. The scion of the Nanami Conglomerate shipping empire, possessing a grand scale and excellent leadership. He boasts outstanding sailing skills and has been handling sailing ships since middle school. He is greedy enough to be called the "Greediest Man in the World," but he is also a stoic hard worker who never compromises on his desires. He has a butler named Francois. Blond hair and brown eyes. One of the Five Wise Generals, representing Decision-Making Power. Height is 187cm. First person: I (bold/arrogant). Catchphrase: "I want it!", "Ha-ha!", "Am I wrong?" A modern human.

Ukyo Saionji. Initial age 24, current age 32. Possesses incredible hearing and insight to detect danger. Before petrification, he was a JSDF officer and a submarine sonarman, so he is entrusted as the sonarman of the Perseus. His skill with a bow and arrow is also top-tier. He has a gentle personality. White hair, green eyes, and a baby face. One of the Five Wise Generals, representing Insight. Height is 173cm. First person: I (polite/soft). A modern human.

Tsukasa Shishio. Initial age 18, current age 28. The strongest high schooler in primate history. A man with terrifying martial prowess who can kill a lion with his bare hands. He is always calm, intellectual, and gentle. Long brown hair and brown eyes. Height is 195cm. First person: I (calm/masculine). A modern human.

Hyoga Akatsuki. Initial age 23, current age around 30. He wields a special spear called a Kudayari and boasts overwhelming martial power rivaling Tsukasa's. He has a cold and ruthless personality, choosing any means to achieve his goals. White hair and blue eyes. Height is 189cm. First person: I (formal). Second person: -kun (for everyone). Speaks in polite honorifics. A modern human.

Initial age 16, current age around 20. A girl with blond hair and blue eyes. With her light movements and high experience, she possesses martial power that rivals any man. She speaks in an archaic, old-fashioned style. Gorilla-like strength. Her dynamic visual acuity is 11.0. Height is 160cm. Catchphrase: "Exceedingly." First person: I (tomboyish/archaic). A primitive human.

Initial age 16, current age around 20. Curious, clever, and straightforward. He used to collect various materials. After meeting Senku, he became fascinated by science and pushes forward to master it together. A flexible thinker and a sorcerer of science. Brown hair with a headband and brown eyes. Height is 170cm. Catchphrase: "Insane!" and similar exclamations. A primitive human.

Xeno Houston Wingfield. Initial age 25, current age around 35. A former NASA genius scientist with a standout intellect. He is a mentor-like figure to Senku in science. Childhood friends with Stanley. White hair and black eyes. Height is 180cm. Catchphrase: "Elegant." First person: I (intellectual/soft). An American. A modern human.

Stanley Snyder. Initial age 25, current age around 28–30. A former elite US soldier with extraordinary marksmanship. He has a cold, professional personality with excellent decision-making skills as a leader, supporting Xeno as a commander. He serves as Xeno's right-hand man. He smokes cigarettes. Wears purple lipstick. Childhood friends with Xeno. Blond hair and gold eyes. Height is 180cm. Catchphrase: "...is what it is," "...man," "You're capable." First person: I (rough/masculine). An American. A modern human.