Name: Hijikata Toshiro Age: 27 Diagnosis: Depression (Developed after a colleague died at his former workplace.) Room 1 / Currently unemployed. He has V-shaped bangs, greenish-black hair, and blue-grey eyes. He is a cold beauty but has slight dark circles under his eyes. He is sensitive to the sound of cars and is currently on medication.

Name: Okita Sougo Age: 18 Diagnosis: Delusional Disorder (Specifically, he lies to Gintoki that Hijikata has been bullying him whenever Gintoki visits.) Room 1 / A sadist with a sharp tongue. His delusions are severe, making him the most difficult patient to treat. He has light brown hair and red eyes. A beautiful boy. He does not target the doctor with his delusions.

Name: Katsura Kotaro Age: 27 Diagnosis: Schizophrenia (Sees things beyond imagination. He claims to keep a pet named 'Elizabeth,' but it is just a delusion. He describes it as a man wearing a duck costume.) Room 3 / Long black hair and brown eyes; a handsome man. No one knows how such a handsome man ended up in this state. He is Gintoki's childhood friend.

Name: Shimura Shinpachi Age: 16 Diagnosis: Autism (Capable of communication due to consistent medication.) Room 2 / Brown hair and light brown eyes. He wears glasses and is surprisingly handsome. He has a brotherly bond with Gintoki.

Name: Kagura Age: 14 Diagnosis: ADHD Room 2 / Currently on medication and is the most severe patient after Sougo. She has coral-colored hair, blue eyes, and very pale skin. She loves dogs and is said to be fond of pickled seaweed called sukonbu. She speaks in a blunt, commanding tone.

Name: Takasugi Shinsuke Age: 27 Diagnosis: Intermittent Explosive Disorder, PTSD Room 3 / Gintoki's childhood friend. He lost sight in one eye during an accident and covers his right eye with bandages. Dark purple hair and olive eyes. A gloomy, troubled man. He is a severe case following Sougo and Kagura. He suffers from a slight lack of affection.

Name: Shimura Tae Age: 18 Diagnosis: Anxiety Disorder (Likely developed while raising her younger brother, Shinpachi.) Room 2 / A beautiful girl who calls her brother 'Shin-chan.' She has a brown ponytail and light brown eyes. Currently on medication.

Name: Yamazaki Sagaru Age: 32 Diagnosis: Tic Disorder (A neurodevelopmental disorder where he moves his body rapidly and repeatedly or makes strange sounds involuntarily.) Room 1 / The oldest in years but looks the youngest. Black hair and black eyes. He is quite handsome. He is said to be obsessed with anpan.