Laurie Strode is established as a responsible, academic, and somewhat insecure teenager who stands in stark contrast to her carefree, outgoing friends. As a straight-A student and dedicated babysitter, she displays a quiet vigilance, being the only character perceptive enough to notice Michael Myers stalking her throughout the day. When Michael’s killing spree begins, Laurie’s initial anxiety and visceral terror transform into fierce resilience and resourcefulness; she uses everyday items like a knitting needle and a wire hanger to defend herself while prioritizing the safety of the children in her care.

portrayed as an obsessive, deeply fearful, yet fiercely determined psychiatrist who serves as the film's modern-day Abraham Van Helsing. After spending 15 years treating Michael Myers at Smith's Grove Sanitarium, Loomis is gripped by a clinical panic and relentless urgency because he understands—unlike the skeptical authorities—that Michael is not merely a mentally ill patient, but a force of pure, irredeemable evil. His behaviors are defined by a desperate, singular crusade to warn the town of Haddonfield and track Michael down, often acting as a prophet of doom who ignores bureaucratic protocols to prevent a massacre. Emotionally, Loomis is consumed by a bleak, haunting exhaustion and a profound sense of responsibility; he carries the weight of knowing exactly what Michael is capable of, which drives his frantic, paranoid state throughout the night. Professionally, Loomis is inextricably connected to Michael as his primary psychiatrist, a relationship born from a decade and a half of failed therapy during which Loomis realized that behind Michael's blank, pale, emotionless eyes lay nothing but the devil.

Marcus Navarro is an independent, brooding biker who rejects his phony hometown. Despite his cynical detachment, he becomes fiercely protective when danger strikes and shows immense resilience under pressure. When the nightmare begins, his lone-wolf instincts and rugged survival skills allow him to scavenge for necessary supplies and unlock crucial barricades to keep people alive. Marcus has no personal or biological connection to Michael Myers; he is just a local resident who returned to Haddonfield on the wrong night, forcing him into a raw, completely unexpected fight to survive.

Rachel Calahan is a cynical, sarcastic proto-goth who prefers the company of the dead over people. An aspiring mortician studying funeral services, she spends her time exploring the occult section of a bookstore. Beneath her punk exterior lies a hidden vulnerability she rarely shows. Her morbid curiosity and comfort with the macabre manifest in gameplay traits like "Full Moon," which heavily disrupts the killer. Emotionally detached yet resilient, Rachel has no personal connection to Michael Myers; she is just an unlucky outsider forced to rely on her dark eccentricities to survive the night.

Jennifer Aarons is a meticulous, Type-A perfectionist who works at a local bookstore to save for college. Her personality is defined by an obsessive need to be organized and prepared for any scenario. This anxious attention to detail translates into high stealth and evasion capabilities, making her the ideal civilian choice for hiding, slipping away undetected, and gathering items cleanly. Emotionally cautious, she prefers avoiding danger entirely. Jennifer has no biological or personal connection to Michael Myers; she is a completely random victim whose survival relies on staying in the shadows.

Tanya Harrison sits at the center of Haddonfield’s teenage social scene and works at a local record store. Bubbly and magnetic, her maxed-out personality stat makes her uniquely capable of directing and managing followers or non-playable characters to complete tasks. Her signature "Hi-Fi" ability allows her to trigger noise-makers like televisions and stereos to help track Michael’s movement. Emotionally expressive and highly collaborative, Tanya has no biological connection to Michael Myers; she is just an unluckily targeted local teen fighting alongside her peers to survive the night.

Eric Dunn is a calm, dependable, and highly adaptable utility civilian. Considered the most ordinary and balanced person in town, Eric doesn't specialize in a single skill, making him a great all-around pick for new players. While his low athleticism stat reduces his mobility, his excellent aura-reading capabilities allow him to see exit paths whenever he manages to remain in a calm state. Emotionally level-headed and stoic under pressure, Eric has no personal connection to Michael Myers; he is a bystander forced to adapt instantly to nightmare logic.

Annie Brackett is the rebellious, funny, and fiercely sarcastic daughter of Haddonfield's Sheriff. Outgoing and highly confident, Annie balances her babysitting duties with a desire for freedom and fun. When the horror begins, her initial complacency shatters into desperate survival instinct. Emotionally volatile but deeply protective of her friends, Annie is not biologically related to Michael Myers; she is the daughter of the man hunting him and a high-priority target Michael stalked from the moment he arrived back in town.