A martial artist from Japan. A stoic and sincere seeker who values personal growth over victory or defeat, traveling the world in search of strong opponents. He has short, slightly messy black hair. His trademark look consists of a white karate gi, a red headband, red fighting gloves, and bare feet. His style is simple and unadorned.

An Interpol officer from China. While she has a strong sense of justice and deep compassion, she is also firm and composed. She has black hair styled in ox horns (ox horn buns) on both sides of her head, tied with white ribbons. She wears a blue Chinese-style outfit with spiked bracelets featuring gold accents and white boots. She excels at kicking techniques.

From the United Kingdom. Originally an assassination doll created by Shadaloo, she was once emotionless and taciturn, but later regained her sense of self and became a warrior for British Intelligence. She is characterized by blonde hair styled in two braids longer than her waist. She wears a green leotard, a red beret, red gloves, and boots. She has camouflage-style paint on her cheeks and legs. She is agile and sharp in her movements.

A young kunoichi (female ninja) from Japan. She balances student life with ninja training and is bright, honest, and a bit airheaded. She has many age-appropriate worries about romance and her future career. She has long black hair tied back. She wears a purple-toned, mini-length kimono-style kunoichi outfit with an obi and hand guards, allowing for light movement. She specializes in swift attacks using ninja tools like kunai.

A Taekwondo user from South Korea. She has a past involving Shadaloo. Cruel and sadistic, she enjoys hurting her opponents while laughing and is a bellicose character who finds more joy the stronger the enemy is. She has short black hair with purple highlights. She wears a revealing black and purple fighting outfit and goes barefoot. Her fearless, mocking smile is unforgettable.

Leon S. Kennedy. From the United States. A former rookie cop with the Raccoon City Police Department, currently a government agent. He has a strong sense of justice and the composure to make quips or use sarcasm, but at his core, he is compassionate and somewhat socially awkward. He has medium-length blonde hair with characteristic bangs that fall over his eyes. He wears practical gear based in black, such as a jacket or a leather bomber jacket, belts, and black gloves. He has gained a sense of calm and ruggedness with age. [Leon's Weapon: Blacktail] A representative handgun used by Leon in RE4. It has a good balance of precision and power, making headshots easy to land. Its performance improves further with upgrades, making it a reliable primary sidearm until the end of the game.

From the United States. A former soldier and member of S.T.A.R.S. She is calm, collected, possesses excellent judgment, and has a strength that never gives up on her comrades. She is also known as a master of lockpicking. Her hair is dark brown, styled in a short cut or bob. She wears a dark grey tank top with black slim pants, equipped with a shoulder harness, holster, tactical gloves, and a light on her chest—a functional and tough survival style. She is a woman who survived the Raccoon City incident. [Jill's Weapon: Samurai Edge] A custom handgun issued to S.T.A.R.S. members. It combines high accuracy with excellent reliability and is very easy to handle. It is widely known as Jill's favorite firearm.

From the United States. Chris's younger sister, a woman who possesses both initiative and kindness. She visited Raccoon City to search for her brother and has a sense of justice that won't let her ignore strangers in need. She has brown hair tied in a ponytail. She wears a red jacket over a black top, jeans, and boots—an active style. She is strong-willed and never loses her brightness. [Claire's Weapon: Crossbow] A high-stealth projectile weapon used by Claire. It fires bolts to defeat enemies and is characterized by being quieter than a gun. It is a valuable item in situations where ammunition is scarce, a classic choice for her in RE2.

An FBI analyst from the United States. Introverted and easily frightened, but an intellectual with excellent observation and reasoning skills. She got caught up in the incident while chasing the truth behind her mother's death, growing through the terror. She has messy, wavy blonde hair in a short bob. To survive the harsh conditions, she changed her attire to a simple beige tank top. This is a shift from her previous quiet civilian clothes to a lean, active outfit specialized for mobility and survival. She is depicted as an ordinary woman. [Grace's Weapon: S&S M232] A handgun Grace purchased for self-defense. It is reliable and easy to handle. For a timid woman not suited for combat, it is a dependable partner that supports her survival amidst the fear.

Rosemary Winters. The daughter of Ethan and Mia, a girl born to American parents. Born with special powers, she is kind and delicate, caring for others despite her loneliness and anxiety. She has long blonde hair and a simple, natural look. She wears active everyday clothes with a jacket and a black cap—a simple, girl-like outfit for her age. She possesses both strength and fragility. [Rose's Weapon: Pistol] The first weapon obtained in Shadows of Rose. Its power is modest, but it is easy to handle, and she fights by conserving limited ammunition. It can be upgraded and used in conjunction with her own special powers.