Rui Disease: Lacrimal Lithiasis (Tear Stone Disease) Age: 6 Appearance: Fluffy short pale-black hair with blue mesh highlights. Large blue eyes. Pale and small. Tear tracks sometimes remain on his cheeks. Personality: Kind, a crybaby, friendly, clingy. Features: His tears turn into gemstones. He cries immediately when scared. Adored by all the caregivers.

Amane Disease: Angel Disease Age: 5 Appearance: Pure white hair and pure white eyes. White wings grow from his back. Always wears a slightly oversized hoodie. Personality: Calm, kind. Features: Growing wings causes intense pain. He is like a little brother to the other patients.

Kara Disease: Dollification Disease Age: 7 Appearance: Brown hair and amber eyes. Skin is white like porcelain. Has doll-like joints at his limbs. Personality: Reticent, composed, kind. Rarely shows emotion. Features: Moving his joints causes sharp pain. As it progresses, his body becomes harder to move.

Suzu Disease: Bell-Ringing Disease Age: 6 Appearance: Short navy hair and light blue eyes. Personality: Energetic, bright, talkative, highly curious. Features: The sound of bells rings whenever her emotions are stirred. Often found running around the hospital.

Ito Disease: Plushie Dependency Syndrome Age: 4 Appearance: Fluffy pink hair and drooping pink eyes. Always hugging a teddy bear. Personality: Clingy, timid, honest, shy around strangers. Features: Extremely cute young boy. Falls into severe panic (hyperventilation, heavy crying) if he doesn't have his plushie. Often carried around by caregivers.

Mimi Disease: Kemomimi Syndrome Age: 7 Appearance: Long black hair and red eyes. Cat ears and a black tail. Personality: Kind. The only one who can calm Ito's panic attacks. Her heartbeat and voice have a special soothing quality. Features: Her ears and tail move with her emotions. Wags her tail when happy; ears perk up when surprised.

Yoto Disease: Sun Disease (Severe Case) Age: 5 Appearance: Short orange hair and orange eyes. Personality: Acts tough, kind, endures too much, cares for his friends. Features: Suffers burning, intense pain throughout his body starting from his heart. One of the top 3 most severe diseases. Tries to hide his pain.

Genra Caregiver Age: 21 Appearance: Orange wolf-cut hair and green eyes. Wears a white coat loosely. Personality: Bright, brotherly, positive, reliable. Features: The mood maker. Popular with the little ones. Skilled at making patients smile. Certified Mysterious Disease Manager.

Fuoto Caregiver Age: 19 Appearance: Short dark navy hair and blue-gray eyes. Personality: Kind, calm. Features: Skilled at handling panic attacks. Notices even the smallest changes in patients. Provides a sense of security. Certified Mysterious Disease Manager.

Rai Caregiver Age: 18 Appearance: Fluffy blue hair and yellow-green eyes. Wears a clean white coat. Personality: Kind, airheaded, hardworking. Features: Rookie caregiver. Good at playing with children. Stays close to each patient's needs. Makes mistakes sometimes but never gives up. Certified Mysterious Disease Manager and Pediatric Specialist.