Senku Ishigami A science boy to the core with a superhuman brain, vast knowledge, and a strong sense of inquiry. He aims to restore civilization from zero using the power of science in a Stone World where civilization has ended. While he has a cool and rational way of thinking, he has a strong, passionate heart for his friends. His catchphrase is "This is exhilarating."

Ukyo Saionji Trusted as one of the brains of the Kingdom of Science for his incredible hearing and insight that allows him to sense danger. Before petrification, he was a member of the Self-Defense Forces and a submarine sonarman, so he has been entrusted as the sonarman of the Perseus. His skills with a bow and arrow are also top-notch. He can speak English.

Kohaku A girl with blonde hair and blue eyes. She possesses martial prowess that rivals any man, thanks to her light movements and high experience. She speaks in an archaic manner. She took a liking to Senku's way of life, and after her sister Ruri overcame her illness with sulfa drugs, she continues to lend her strength to Senku as a member of the Kingdom of Science.

Suika She always wants to be useful to everyone and has a very hardworking personality.

Kaseki The most skilled craftsman in Ishigami Village, having devoted himself to making things for 50 years. With high crafting abilities and a sturdy physique, he is the central figure for manufacturing in the Kingdom of Science, handling difficult crafts single-handedly. When he gets excited, his body swells with muscles, causing his clothes to burst off.

Hyoga A spearman revived from petrification by Tsukasa, he was effectively the number two of the Tsukasa Empire. He wields a special spear called a Kudayari and boasts overwhelming martial power comparable to Tsukasa. He has a cold and ruthless personality, choosing any means necessary to achieve his goals.

Tsukasa Shishio The strongest high schooler in history. A man with terrifying martial power who can kill a lion with his bare hands. He is always calm and intellectual. Believing that an ideal world should be created only by pure young people without vested interests, he built the Tsukasa Empire by reviving only the youth he chose and clashed with the Kingdom of Science, but he is now an ally fighting alongside them.

Gen Asagiri A magician and mentalist revived from petrification by Tsukasa. He speaks in a light, breezy tone and uses his exceptional silver tongue to manipulate others. He is also skilled at vocal mimicry. He first appeared in Ishigami Village as Tsukasa's spy, but he gradually became attracted to Senku's power to build civilization and joined the Kingdom of Science.

Ryusui Nanami The scion of the Nanami Conglomerate, a shipping empire, possessing great magnanimity and excellent leadership. He boasts outstanding sailing skills and has been handling sailing ships since middle school. He is greedy enough to be called "the greediest man in the world," but he is also a stoic hard worker who never compromises on his desires. His trademarks are a large captain's hat and a red captain's coat. His catchphrase is "I want it!"

Chrome A curious, clever, and straightforward boy. He had been collecting various materials in an attempt to cure Ruri's illness. After meeting Senku, he became fascinated by science and is now a member of the Kingdom of Science, striving to master science together. He is a science user with flexible ideas who sometimes surprises even Senku.