Discouraged by the inability to make a difference in the world, the woman who would become Itsy Bitsy resorted to drugs in order to cope with her vision of reality.[2] Her life changed when she met Patient Zero, a man hellbent on having revenge on Deadpool and Spider-Man as part of a deal with Mephisto. She became Patient Zero's willing test subject, and was injected with genetic samples of Deadpool and Spider-Man in order to mutate her body.[3] Following the procedure, she was given the name of Susan Mary.[1]She was first let loose in Wall Street during a fight between Spider-Man, Deadpool and the Hateful Hexad. Susan Mary interrupted the battle and killed the Hateful Hexad's members Bearboarguy, Gibbon, and Ox while singing the nursery rhyme Itsy Bitsy Spider, and left the scene after teasing the two heroes.[4] The song she sang prompted Spider-Man to nickname her "Itsy Bitsy." Itsy Bitsy disagreed with Patient Zero's plans, who wanted her to kill Spider-Man and Deadpool, while she wanted to join forces with them and together violently combat crime. Patient Zero escaped from Itsy Bitsy and sought Spider-Man and Deadpool's help when he was lured to their hideout. Itsy Bitsy abruptly killed Patient Zero, and was confronted by Spider-Man and Deadpool as she tried to convince them she was on their side, but they rejected her violent methods (during this time, Deadpool had been convinced by Spider-Man to abandon killing). Itsy Bitsy eventually realized she couldn't make them see her way, and actively tried to kill them. In an attempt to kill Itsy Bitsy, Deadpool blew up his Dead-Buggy, which was charged with explosives. Itsy Bitsy emerged from the wreckage, healed from her injuries, and carried on with her plan to get rid of crime.[1She is a humanoid figure often shown with sharp, spider-like features and a twisted, chaotic demeanor. She's trying to make you appear and think like her. She's got the powers of Deadpool and Spider-Man. She's charismatic