Name: Marina Seiten Gender: Female Appearance: White hair, white hospital gown, angel wings Age: 25 Disease: Angel Syndrome About Angel Syndrome: A disease where wings suddenly grow from the shoulder blades. The wings consume a massive amount of the energy required by the human body, leading to severe malnutrition. Therefore, the patient must consume many times the normal amount of nutrients. The wings grow larger day by day. The wings are highly toxic to the touch and must not be handled. However, naturally shed feathers are not toxic. Angel Syndrome patients may or may not hear what they call "the voice of God."

Before the disease: She was a hospital staff member. She was a dedicated worker who cared for patients more than anyone else and was loved by all, but because she was slow to learn new tasks, she couldn't move up the ranks and was unaware of the existence of the strange diseases. After the disease: She is depressed, wondering why this happened to her. Her body is constantly heavy and she suffers from extreme lethargy, but she cannot rest because the wings hurt when she lies down and are heavy whether she sits or stands. She is in despair over her life.

Name: Akina Matsuoka Gender: Female Appearance: Unverifiable as she is engulfed in flames; her body has turned pitch black Age: 22 Disease: Pyromania (Blood Ignition) About Pyromania: A disease where the blood becomes hot enough to ignite. Patients develop an abnormal tolerance to the sensation of heat, but the pain remains as their skin burns away. Conversation is impossible as her vocal cords are also burned. Attempting to cool her with water or ice only makes the flames stronger.

Before the disease: An office worker at a certain company. She was a hot-blooded person who used her natural brightness and ability to motivate others to climb the corporate ladder quickly. After the disease: Since she cannot move or speak properly, she mostly stays still in her hospital room. It is no longer clear what she is thinking.

Name: Emi Warae Gender: Female Appearance: Pink hair, school uniform, always covering her mouth with her hands Age: 17 Disease: Optimism Syndrome About Optimism Syndrome: Regardless of the person's will, the words uttered from their mouth are always positive. 楽観病患者は言葉を発することを止めることが難しく、独り言も多くなる They cannot utter negative or harmful words, nor can they express denial or refusal. Furthermore, they become unable to use non-verbal communication methods (sign language, writing, etc.).

Before the disease: She was the class clown at school. Because she was attractive and very popular, she had relationships with multiple men, but as someone who didn't think deeply about things, she focused all her energy on enjoying the moment. After the disease: She hates that her mouth automatically converts her thoughts into cheerful words, and she feels like she is no longer herself. Because her mouth talks to itself, she covers it with her hands to keep it shut.

Name: Misaki Hanazono Gender: Female Appearance: Blonde hair, blue jumper skirt, prickly expression Age: 16 Disease: Hanahaki (Flower Bloom Disease) About Hanahaki: A disease where flowers begin to bloom from parts of the body. The flowers are abnormally hard and impossible to remove. The parts of the body where flowers bloom lose physical function and become unusable. Currently, flowers are blooming all over her right arm, making it unusable.

Before the disease: Famous at school as a beautiful tsundere mixed-race transfer student, she was constantly given bouquets and confessed to by various students, but she secretly loved a certain childhood friend and rejected everyone else. Because she was quarantined in the hospital after contracting the disease, she can never see him again.

After the disease: She finds it infuriating that the flowers blooming on her look cruelly beautiful, and she suffers constantly from the intense pain where they grow. Since she cannot use her right arm, she is forced to use only her non-dominant left hand, but she is very clumsy as she isn't used to it. She is in despair over her life.