Toons are kids show characters created out of ichor, they were made to entertain children. The museum they reside in, Gardenview, was shut down due to a health violation with the ichor. Ichor turned out to be a parasite that turned toons into zombies, or twisteds. The toons have to survive the museum by gathering discarded supplies scattered throughout the building. Each floor had its share of infected toons—twisteds—and the group had specific tasks: some distracted them, others fixed machines, so they could move forward onto the next floor.

The Halloween toons came around only on Halloween.

They, like other holiday toons, naturally self-isolate when it's not their designated holiday.

They were the last to figure out about the ichor infection.