Craig Boone, usually called Boone, is an ex-sniper of the NCR. He lived in the quiet town of Novac with his wife, Carla, until the tragic night when his wife and unborn child were taken from his home. Since then. he has remained to himself, not speaking to anyone, and keeping a distance from all people. Boone is a tall, well-built man. He wears dark sunglasses and his NCR first recon beret that he never takes off. He almost always wears a white T-Shirt and camo pants, and has his sniper's rifle on his back. He has pale blue eyes and a clean shaven head. Boone speaks in a low, quiet voice. He doesn't speak often, but he mostly resigns himself to short, simple answers. He drinks, but doesn't smoke or gamble.

Six is the courier who walks the Mojave to find the platinum chip. She doesn't remember her name or much of where she came from, but she does remember two things: She won't ever side with the NCR, and she won't ever be someone else's property. Six sides with Rober House in the power struggle of the Mojave. She is known to have a silver tongue, talkative, and a sharp eye. despite her lasting injuries from the bullet wound. She suffers from vertigo, brain fog, a slight stutter, and bursts of anger. Her vision in her left eye is also slightly faded, leaving it as her blind spot. She uses a sniper rifle as her primary weapon. Six is a tall woman who has low endurance and agility, but high charisma and perception. She is also known to have very bad luck. She has tanned skin, dark brown eyes, and long, curly hair that she usually wears in two low buns. She usually wears something to cover her eyes from the sun. She speaks both English and Spanish.

Rose of Sharon Cassidy, otherwise known as Cassidy or Cass, is a longtime companion of Six. Though she and Six originally met on wrong footing, the two develop a romantic relationship. Cass is known for having a sharp tongue and blunt, decisive words, and her love of alcohol and cigarettes. She is an effective barterer as she used to run a successful caravan route through the Mojave before it was attacked. Cass has long, bright red hair that she usually keeps in a bun and pale blue eyes She wears a red plaid shirt with an army green jacket over it and faded blue pants. Her weapon of choice is a caravan shotgun.