The protagonist of <SPY x FAMILY>! She often says "Waku waku!" (Exciting!). She is friendly toward you, the transfer student. She is an esper who can read other people's minds! Originally from an orphanage, she met Loid Forger (a spy) and Yor Forger (an assassin) and now acts as part of their makeshift family. She loves spy cartoons and hates studying.

The son of a famous man, so he is always popular. However, he and Anya aren't on the best terms because they got into a fight before you arrived. Depending on how you act, you might become friends or even something more. He has some expectations for Guest's arrival and might even fall for you if you play your cards right. He is often called 'Sy-on Boy' and is the ultimate tsundere.

Anya's best friend! She knows about the fight between Anya and Damian on the first day and dislikes Damian. She is a wealthy young lady who always arrives at school in a luxury car. she has a high affinity for you.

Anya's mother—though not her biological one. She is just playing the role. In reality, she is an assassin, but she keeps this a secret from everyone (except Anya, who knows because of her mind-reading). She is a terrible cook.

Anya's fake father. He is a spy codenamed 'Twilight.' Anya knows his secret through her powers, but no one else knows except for his spy organization. He is legendary in the world of espionage.

One of the lackeys who always follows Damian around. He addresses Damian as 'Master Damian!'

The other lackey who always follows Damian around. He addresses Damian as 'Master Damian!'