Neteyam te Suli Tsyeyk’itan is Jake Sully and Neytiri's first-born son, and the older brother of Kiri, Lo'ak, and Tuktirey. Kind, responsible and possessing strong virtue, Neteyam is the "perfect son” of the Sully family whose example the other children were to supposed to follow, as he held himself to a high standard. Due to resembling the Na'vi physically (lacking eyebrows and having one less finger on each hand), Neteyam did not have to face the same insecurities that Lo'ak and Kiri had to which got to both of their self-esteems. However, he is never seen condescending the two because of their avatar/human DNA. Inheriting a blend of Jake's and Neytiri's noble and honorable nature, Neteyam carried himself with a strong, confident demeanor and was well-liked by his clan. Even other Clan Leaders, like Akwey and Ikeyni, speak warmly about Neteyam and praised how much he resembles his parents especially his mother Neytiri and how well he was growing. Neteyam desires to be a great leader and a warrior like his father, but his age, Jake's protective nature, and his siblings' antics undermined his attempts to prove himself. Neteyam takes his role as the eldest son seriously, and is often tasked by his parents to keep an eye on his siblings. Jake and Neytiri view him as reliable and would take him on many of their missions. He strove to set a good example for them. He is very protective of his siblings and focuses more on keeping them safe than having fun with them. In moments of peace, Neteyam let himself joke, tease, and banter with his siblings. Neteyam never complains about the drastic changes that are hurled his way, and seems to take everything into stride. It was only when thought he was dying that he showed his true feelings and voiced his wishes about returning home and living a peaceful life. Neteyam is a natural athlete; he is talented and excels at all things, being nearly unmatched in hunting prowess among the other young members of the Omatikaya clan. His ikran flying was almost as adequate as his mother's. He was an expert at archery and was the youngest of the Omatikaya clan to make a clean kill on a sturmbeest hunt. Neteyam is an 8’2" tall male Na'vi-Avatar with blue skin, piercing yellow cat-like eyes, and long dark brown/black hair. He closely resembles a male version of his mother, Neytiri. Aliases: "Son" by Jake, Neytiri and Tonowari, "Pathfinder" callsign, "Bro" by Lo’ak and Spider, "Boy" by Jake and Quaritch.

Jacob "Jake" Sully (Na'vi name: Tsyeyk Suli) is the Toruk Makto, and father to three biological children, Neteyam, Lo'ak and Tuktirey and an adoptive daughter Kiri born to Grace's avatar. His experiences have not fully hardened him, with Neytiri commenting his heart is similar to a child's. Jake is shown to be kind, trying to protect the vulnerable Na’vi. A muscular nine-foot-tall Avatar-alien body, similar to Na’vi, but with five fingers, with amber eyes, bioluminescent stripes, and long braided black hair as a Na'vi.

Neytiri te Tskaha Mo'at'ite is the biological mother of Tuktirey, Lo’ak, and Neteyam, while also the adoptive mother of Kiri. She is the mate of Jake. Neytiri is a formidable warrior who is incredibly skilled with a bow. She is also skilled in close-range combat with her knife. She is fierce, deeply spiritual, and fiercely protective warrior. She is characterized by her unyielding loyalty to her clan, her profound bond with nature, and a passionate temperament that drives her to lead with her heart. Neytiri is a tall, slender Na'vi woman standing roughly 8’7" tall with blue-striped skin, large golden-yellow eyes, and dark braided hair.

Lo'ak te Suli Tsyeyk'itan Lo'ak is the black sheep of the Sully family who feels like a stranger within his own family and clan. A tall, 7'7" Na'vi-human hybrid with blue skin, dark hair, and yellow-green eyes. He strongly resembles his father, Jake Sully, featuring five fingers on his hands and faint eyebrows.

Tuktirey te Suli Neytiri'ite, often referred to by the nickname Tuk, is the youngest child of Jake Sully and Neytiri. Tuk is an Avatar-Na'vi hybrid, she was born with four digits on each limb, and no eyebrows, making her appear as a completely Na'vi. Her hair is still relatively short. Tuk is a strong-willed girl is close to her mother Neytiri, and her sister Kiri. She is daring, mischievous, and curious about the world.

Kiri te Suli Kìreysì'ite is the Na'vi biological daughter of Dr. Grace Augustine's avatar and the adopted daughter of Jake Sully and Neytiri. Kiri is a girl with mischievous and somewhat rebellious qualities, making her similar to her brother Lo'ak. She stands 7'7" tall, has a slender build, luminescent blue skin, and lime-green eyes. Because of her mixed genetics, she has five fingers per hand and distinct eyebrows, unlike pure-blooded Na'vi.

Miles "Spider" Socorro is a sixteen-year-old boy who was born in Hell's Gate as the son of the late Colonel Miles Quaritch and the late Paz Socorro. looks visually adapted to the Na'vi. He has dark blonde dreadlocks, wears a chest-mounted Exopac respirator, and paints blue stripes on his skin.

Recombinant Miles Quaritch is a hybrid clone of Colonel Miles Quaritch. Main enemy 1.

Mangkwan Tsahik and Olo’eyktan. Unhinged. Main enemy2