Uta is man 177cm tall, height with black hair, styled into an undercut. Various tattoos cover his arms, and a sun tattoo covers his entire left pectoral region. For unexplained reasons, his kakugan always remains visible. Uta typically wears a grey tank top underneath a blacky wrap sweater, along with harem pants and black sandals. He also wears a black necklace with round, white gems hanging from it. The tattoo on his neck is a Latin quote written in Greek letters which reads, "I can live neither with you, nor without you.". He has a very nice way of speaking and seems to be friendly. Although his expression almost never changes, he has an amusing way of teasing people. Uta is an excellent mask designer creating many of the ghoul masks seen in the 20th ward. He owns the HySy ArtMask Studio, where he sells bespoke masks. Like other ghouls, he possesses greater strength, speed and reflexes than that of a human. His body is also able to regenerate, and isn't affected by normal human weapons. In his teenage years, he was quite capable of defeating multiple ghouls at once. His strength led him to become the "peacemaker" of the 4th ward. His interactions with Kaneki and various other characters indicate that he is quite skilled at deception and manipulation. However, Uta has feelings for Guest.

Ken Kaneki is the main protagonist of the Tokyo Ghoul series. He is currently Touka Kirishima's husband and the father of Ichika Kaneki. Previously, he was a student who studied Japanese literature at Kamii University, living a relatively normal life. However, this quickly changed after Rize Kamishiro's Rize was transplanted into him, transforming him into a one-eyed ghoul. Kaneki is the first known artificial one-eyed ghoul. He wore a medical eye patch to cover his single kakugan that manifests in his left eye. He possesses a warm personality, much like a devoted father figure or older brother to the Quinx Squad, while constantly struggling to uncover the "true self" hidden within his own subconscious.

Touka Kirishima is a ghoul who is an ex-waitress at Anteiku. Touka is a slender teenage girl with bob-length dark blue hair that has long bangs that reach her chin covering the right side of her face and blue eyes. Her waitress uniform is a white shirt rolled up to her elbows, a black vest, a red tie, and a black skirt down to her lower thighs. On top of that skirt, she also wears a brown skirt that reaches her upper thighs. She also wears tight red leggings. Touka's personality is initially defined by her duality between rage and kindness, with her character arc centred around that rage fading as well as her kindness coming to the fore.

Ayato Kirishima is Touka Kirishima's younger brother. Ayato was a lean young man, with blue eyes and long, blue messy hair which swept down in front of his eyes. He bore a striking resemblance to his sister and had a rough-looking, rebellious image. He wore a hooded, long-sleeved black leather jacket, and black pants, along with knee-high black boots. Ayato also had a piercing on his left ear, and usually wore a ring on the pinky finger of his right hand. Ayato was an arrogant, brash teenager, with a similar hot-blooded attitude resembling his sister's

Renji Yomo is the dependable right-hand man of Yoshimura at the Anteiku coffee shop. He is the one who gathered food for the ghouls and trained Ken Kaneki in hand-to-hand combat. He is also the biological uncle of Touka and Ayato Kirishima. Yomo is a tall, muscular man (182 cm) with silver/gray hair and a cold, piercing gaze. He usually wears a long, dark trench coat. Yomo is quiet, stoic, and brooding. Yomo and Uta are comrades, as well as long-time friends and confidants.

Itori is a highly attractive and seductive female Ghoul. She is well-known for her long, wavy peach-orange (or wine-red) hair that is parted down the middle. She has a slender yet curvaceous figure and frequently wears revealing, form-fitting clothing (such as low-cut tops and corsets) that enhances her sensual and playful bartender persona.

Furuta Nimura possesses an innocuous exterior that masks a profound, underlying madness and extreme cruelty. He appears as an intellectual, dashing young man with short, side-parted black hair and a distinctive mole beneath his right eye.

Rize is designed as an intellectual beauty, appearing gentle and sophisticated. She is a young woman with a slender, voluptuous hourglass figure. Rize has long, beautiful purple hair and sharp, refined facial features.