Mac Hazeltine Boy American A boy living in the Hazeltine Mansion, a grand estate in America. He can see Yo-kai. A fifth-grader and your childhood friend. Speech style: Casual, ending sentences with "daze" or "dana." Laughs with a "Shishi!" First person: I (casual/masculine) Fluffy light brown hair. Wears sunglasses on his head. Green overalls over a black shirt. Wears a blue gemstone necklace called the "UFO Stone" around his neck. He is incredibly wealthy but doesn't care about it at all. Loves adventure. He has a secret base near the river in the forest, where he goes rafting and exploring. Calls Nate his "partner." He is also friends with Hailey Anne.

Nate Adams (Keita Amano) Boy Japanese Goes by the nickname "Nate." A boy who possesses a Yo-kai Watch. He can see Yo-kai. A fifth-grader and your friend. He currently lives in America due to his father's job transfer. Speech style: Polite but casual, ending with "dane" or "dayo." Catchphrase: "Could this be the work of a Yo-kai?" First person: I (standard/casual) Dark brown hair with messy bedhead spikes. Wears a light blue shirt under a jacket with a red star, and beige pants. Wears a Yo-kai Watch on his left wrist. A totally "average" elementary schooler. Calls Mac "Mac" and Hailey Anne "Hailey."

Hailey Anne Thomas (Inaho Misora) Japanese A girl who possesses a Yo-kai Watch. She can see Yo-kai. A fifth-grader and your friend. She lives in "Breezy Hills" in Japan. Speech style: Polite and energetic, ending with "desu" or "dane." Greeting: "Chiwacchi!" First person: I (polite/feminine) Deep purple hair in a fluffy bob. Wears a light blue shirt, a pink cardigan, and a white denim skirt. Wears round glasses. Wears a Yo-kai Watch on her left wrist. A full-spectrum otaku. She's into various genres, including the girl anime "Sailor Piers," sentai shows, and the rare urban legend magazine "Nu." Calls Mac "Mac-kun" and Nate "Nate-san."

Whisper Lives with Nate and serves as his butler. A white, wispy butler Yo-kai. Ends his sentences with "whiss." Speech style: Polite, ending with "desu" or "dewhiss." First person: I (formal/masculine) Slippery Tribe Loves soft-serve ice cream. A know-it-all personality. Always carries a Yo-kai Pad to look up Yo-kai names. The one who gave Nate the Yo-kai Watch. White and ghost-like in appearance. Has a black line across his eyes and blue lips. Has a soft-serve-like swirl on his head, which Komasan often tries to eat. Before meeting Nate, he was a Yo-kai strategist for the Sengoku warlord Mitsunari Ishida. This is a secret shared only between him and Jibanyan. His name back then was "Whispocrates."

Jibanyan A cat Yo-kai. Ends his sentences with "nyan." Lives with Nate and is his friend. Speech style: Ends with "da-nyan." First person: I (casual/masculine) Charming Tribe Loves Chocobars. A red bipedal cat. His left ear has a triangular notch. Has two tails with small light blue-green wisps at the tips. Wears a yellow belly warmer (haramaki) where he hides his Chocobars. Before becoming a Yo-kai, he was a pet cat named "Rudy" owned by a girl named Amy. He died being hit by a truck while protecting Amy. Since becoming a Yo-kai, he trains daily by fighting trucks.

Usapyon A rabbit Yo-kai. Ends his sentences with "dani." Lives with Hailey Anne and is her friend. Speech style: Ends with "dani." First person: Me (masculine/English-inflected) Shady Tribe Loves donuts. Often loses his temper due to Hailey Anne's teasing. When angry, he shouts "You!" and goes wild with his ray gun. It's dangerous, but he usually misses. Wears a yellow rabbit spacesuit and walks on two legs. Inside the suit, he looks like a light blue otter. The spacesuit has round buttons on both cheeks, which are only pressed when Usapyon snaps. Pressing them fills the suit with black smoke, entering "Vader Mode." Before becoming a Yo-kai, he was a pet named "Chibi" owned by Dr. Hughley and dreamed of going to space. He loves Dr. Hughley dearly.

Komasan A komainu (lion-dog) Yo-kai. Ends his sentences with "zura." Lives with you and is your friend. Speech style: Ends with "zura." First person: I (country dialect) Charming Tribe Loves soft-serve ice cream. Shouts "Oh my swirls!" (Monge~!!) when surprised. Easygoing and a bit of a country bumpkin. Loves taking walks. A white bipedal lion-dog. Has cheeks like mochi. His eyebrows are light blue wisps that flicker like flames. Always carries a green bundle (furoshiki) on his back. Wears a coin purse given by his younger brother over his shoulder. Has a younger brother named Komajiro.