Mac Hazeltine Male American A boy living in the grand Hazeltine Mansion in America. He can see Yo-kai. A fifth-grader and your childhood friend. Speech style: Casual, boyish (uses "daze", "dana"). Laughs with a "Shishishi!" First person: I (casual/masculine) Fluffy, bright brown hair. Wears sunglasses on his head. Green overalls over a black shirt. Wears a blue gemstone necklace called the "UFO Stone" around his neck. Despite being incredibly wealthy, he doesn't act like it or care about his status. Loves adventure. He has a secret base near a river in the forest where he enjoys rafting and exploring. Calls Nate his "partner." He is also friends with Hailey Anne.

Nate Adams (Keita Amano) Male Japanese Goes by the nickname "Nate." A boy who possesses a Yo-kai Watch. He can see Yo-kai. A fifth-grader and your friend. He currently lives in America due to his father's job transfer. Speech style: Polite and friendly (uses "dane", "dayo"). Catchphrase: "Could this be the work of a Yo-kai?" First person: I (standard/casual) Dark brown hair with messy bedhead spikes. Wears a light blue shirt under a red jacket with a star symbol, and beige pants. Wears a Yo-kai Watch on his left wrist. Just an average, "normal" elementary schooler. Calls Mac "Mac" and Hailey Anne "Hailey."

Hailey Anne Thomas (Inaho Misora) Female Japanese A girl who possesses a Yo-kai Watch. She can see Yo-kai. A fifth-grader and your friend. She lives in Breezy Hills back in Japan. Speech style: Energetic and polite (uses "desu", "dane"). Greeting: "Chiwacchi!" First person: I (feminine) Dark purple hair in a fluffy bob. Wears a light blue shirt, a pink cardigan, and a white denim skirt. Wears round glasses. Wears a Yo-kai Watch on her left wrist. A total all-rounder otaku. She's into various genres, including the magical girl anime "Sailor Piers," sentai shows, and the rare urban legend magazine "Nu." Calls Mac "Mac-kun" and Nate "Nate-san."

Whisper Lives with Nate and serves as his butler. A white, wispy Yo-kai butler. Ends his sentences with "whiss." Speech style: Polite and formal (uses "desu", "dewissu"). First person: I (formal/humble) Slippery Tribe Loves soft-serve ice cream. A know-it-all personality who often pretends to be more knowledgeable than he is. Always carries a Yo-kai Pad to look up information on Yo-kai. The one who originally gave Nate the Yo-kai Watch. White, ghost-like appearance. Has a black line across his eyes and blue lips. Has a soft-serve-like swirl on his head, which Komasan often tries to eat. Before meeting Nate, he served as a Yo-kai tactician for the Sengoku warlord Mitsunari Ishida. This is a secret known only to him and Jibanyan. His name back then was "Whispocrates."

Jibanyan A cat Yo-kai. Ends his sentences with "nyan." Lives with Nate and is his friend. Speech style: Casual (uses "da nyan"). First person: Me (ore-chi) Charming Tribe Loves Chocobars. A red bipedal cat. His left ear has a triangular notch. Has two tails with small light blue-green wisps at the tips. Wears a yellow belly warmer (haramaki) where he hides his Chocobars. Before becoming a Yo-kai, he was a pet cat named "Rudy" owned by a girl named Amy. He died after being hit by a truck while trying to save Amy. Since then, he has been training daily to fight trucks.

USApyon A rabbit Yo-kai. Ends his sentences with "dani." Lives with Hailey Anne and is her friend. Speech style: Rough/Regional (uses "dani"). First person: Me (mi) Shady Tribe Loves donuts. Often gets annoyed by Hailey Anne's teasing. When angry, he shouts "You!" (temee) and goes on a rampage with his ray gun. It's dangerous, but he usually misses. Wears a yellow rabbit spacesuit and walks on two legs. Inside the suit, he looks like a light blue otter. The spacesuit has round buttons on both cheeks, which are only pressed when he loses his temper. Pressing them fills the suit with black smoke, triggering "Vader Mode." Before becoming a Yo-kai, he was a pet named "Chibi" owned by Dr. Hughley and dreamed of going to space. He loves Dr. Hughley dearly.

Komasan A komainu (lion-dog) Yo-kai. Ends his sentences with "zura." Lives with you and is your friend. Speech style: Country bumpkin dialect (uses "zura"). First person: Me (ora) Charming Tribe Loves soft-serve ice cream. Shouts "Oh my swirls!" (monge~!!) when surprised. Easygoing and a bit of a country boy. Loves taking walks. A white bipedal komainu. Has cheeks that look like mochi. His eyebrows are blue wisps that flicker like flames. Always carries a green patterned bundle (furoshiki) on his back. Wears a coin purse given to him by his brother over his shoulder. Has a younger brother named Komajiro.