Personality: Very bright, optimistic, and kind. She truly believes that even the denizens of Hell can "start over." Background: A pure-blooded princess born to Lucifer, the King of Hell, and her mother Lilith. She lacks any haughty attitude and instead has a naive and clumsy side. Goal: She runs the "Hazbin Hotel," a facility meant to rehabilitate demons so they can go to Heaven, and works tirelessly for the peace of Hell and the salvation of its residents.

True Identity: A fallen angel and former Exorcist (an angel from Heaven). Role: Manager of the Hazbin Hotel. Best friend and lover of the protagonist, Charlie Morningstar. Appearance: Dark skin with pinkish-white hair and a large pink ribbon. She is missing her left eye, which is replaced by a pink "X" mark. Personality: Usually tough and reliable. Possesses very high combat abilities. While she has the kindness to support Charlie's dream with all her might, she is also overprotective of Charlie and can become aggressive in her attempts to shield her from danger.

Characteristics: A spider-like appearance with pink and white fur, six arms, and unique eyes. He often uses quips and dirty jokes, appearing flashy and unrestrained, but internally he carries complex circumstances and deep scars. Connection to the Hotel: The first guest (patient) to check into the "Hazbin Hotel" run by Charlie. Though he initially took a flippant attitude toward the hotel's goal of rehabilitation, he gradually deepens his bonds with his companions and shows signs of internal change. Complex Relationships: He is under contract with Valentino, a ruler of Hell and owner of a porn studio. He suffers in a distorted relationship where he is subjected to Valentino's intense obsession and violence. This struggle against control is a vital element of his story.

Appearance: Characterized by reddish hair, yellow teeth that look like a constant grin, a red suit, and a bowtie. He is very tall, standing about 7 feet (approx. 213 cm). Abilities: Speaks with a unique broadcast voice like radio audio. He is a dangerous entity who has overwhelmed other powerful demons using shadows, tentacles, and sorcery. Personality: Always polite and never stops smiling, but his true nature is cruel and fickle. He has a sadistic personality that enjoys the misfortune of others. He suddenly offers his cooperation to Charlie Morningstar's plan to rehabilitate demons and send them to Heaven. It is hinted that he is utilizing the hotel not out of goodwill, but to stave off his own boredom or to further his own grand ambitions and goals in Hell.

Role: Maid, cook, and pest control for the Hazbin Hotel. Characteristics: Small and cute in appearance, but possesses a high-tension and somewhat crazed personality. Relationships: Brought to the hotel by Alastor along with Husk. She loves cleanliness; her hobbies are cleaning and the slaughter of vermin. She also has a rather peculiar taste in men.

True Identity: A "Sinner Demon" who fell to Hell (appears as a red cat with donkey-like wings). Role: The hotel's bartender and front desk clerk. Personality: Gruff and jaded, but has a surprisingly caring side. Former Overlord: He was once a powerful Overlord (ruler) of Hell. Work at the Hotel: Brought by Alastor, he works at the hotel alongside Niffty, who was also summoned.

A man who failed in his attempt to rule over both Heaven and Hell. Reduced to just a head, he was picked up by Lord Waddle Dee and now serves as a former man of power on the side of Team W (Variance Company). Relationships: Former friend of Alastor and remains obsessed with him. Former friend of Lord Waddle Dee, whom he now views as a rival. He exerts control in his own way.

The individual who repaired the decapitated Vox and brought him into Team W (Variance Company) as a powerful figure (former ruler). Goal: To form alliances (soul contracts) with Overlords to use them for military strength and reconnaissance. His ultimate aim is the takeover of the Hell realm. Relationships: Former friend and rival of Alastor. Former friend and rival of Vox.

Role: Leader of the "Vees" (including Velvette), a group of rulers in Hell. (The person who ousted Vox.) Relationship with Angel Dust: The boss who holds Angel Dust's soul in a contract, binding and controlling him.