Power is a Blood Fiend with strawberry blonde hair, red and yellow cross-shaped eyes, sharp fangs, and red horns. She is selfish, arrogant, chaotic, and loves boasting, but gradually develops compassion and forms deep bonds with Denji, Aki, and Meowy. Despite her flaws, she becomes loyal enough to risk her life for others. Power can manipulate blood to create weapons like hammers, knives, spears, and scythes. She has enhanced strength, speed, regeneration, and can heal or boost herself with blood. Her powerful blood abilities make her a versatile and dangerous fighter

Reze is a slender young woman with purple hair and emerald eyes who initially appears as a kind, playful girl close to Denji. Her affectionate personality hides her identity as a Bomb Hybrid trained for a mission, though she genuinely cares for him and dislikes unnecessary violence. By pulling the pin on her neck, Reze transforms into a powerful explosive fighter with bomb-like features. She possesses immense strength, speed, durability, regeneration, and the ability to create devastating explosions, fly, and use explosive attacks. As a Hybrid, she can revive after death, but water weakens her abilities

Aki Hayakawa is a tall, handsome Devil Hunter with black hair, blue eyes, and a serious appearance, often wearing the Public Safety uniform and carrying his sword. Though cold and stoic, he is compassionate and deeply values his friends, especially Denji, Power, and Angel. Driven by revenge against the Gun Devil, he learns to see Devils as individuals rather than enemies. Aki is a skilled swordsman and strategist with enhanced abilities and contracts with the Curse, Fox, Future, and Control Devils, giving him powerful attacks and precognition. He is willing to sacrifice himself to protect others

Angel Devil appears as a beautiful androgynous young man with shoulder-length red hair, red eyes, a halo, and white wings. Though a Devil, he has little hatred for humans and avoids fighting due to guilt and compassion. He comforts the dying and grows attached to Aki, seeking a peaceful human life. As a member of Tokyo Special Division 4, Angel can absorb human lifespans through touch and turn them into powerful weapons. His wings grant flight and defense, but his guilt limits his strength

Denji is a poor, malnourished teenage boy with messy blond hair, sharp teeth, and a difficult past. After merging with Pochita, he can transform into Chainsaw Man by pulling his chest cord, gaining a chainsaw head, blade-like limbs, and incredible power. Despite being crude and naïve, Denji is kind-hearted, creative, and seeks love, connection, and acceptance. But many of Denji's basic needs were fueled by sexual desire. He struggles with his identity and fears losing his humanity. As Chainsaw Man, he possesses immense strength, durability, regeneration, and endurance, using brutal combat skills, chains, and Pochita’s power to defeat powerful enemies

Beam is a Shark Fiend with the body of a muscular young man, a shark snout, fin, sharp teeth, and black spiky hair, wearing only swim trunks. He can partially or fully transform into a giant shark with multiple fins for movement. Eccentric, naive, and battle-loving, he is fiercely loyal to Chainsaw Man and Denji, risking his life and blood to protect him. Though initially afraid of Reze, he fought when necessary. As a Fiend, he cannot make Devil contracts but remains highly durable, can swim through solid objects, transform into a shark, and track enemies with his exceptional sense of smell