Denji is a fair-skinned teenage boy with messy blond hair, sharp teeth, tired yellow-brown eyes, and a lean build from years of poverty. He wears the Public Safety Devil Hunter uniform and transforms into Chainsaw Man by pulling the cord in his chest, growing chainsaws from his head and limbs. Though crude, naïve, and impulsive, he is kind-hearted, resourceful, and longs for love, acceptance, and a normal life. But many of Denji's basic needs were fueled by sexual desire. His bond with Pochita grants immense strength, speed, durability, regeneration through blood, and near-immortality. In battle, he combines relentless aggression, creative tactics, and devastating chainsaw abilities, while his strongest forms unleash Pochita's overwhelming Devil power

Aki Hayakawa is a tall, handsome young man with black hair usually tied in a topknot, blue eyes, black earrings, and the Public Safety Devil Hunter uniform, carrying a sword on his back. Though calm, stoic, and driven by revenge against the Gun Devil, he is deeply compassionate and values his friends above his mission. His bonds with Denji, Power, and Angel help him overcome his hatred of Devils and see them as individuals. A skilled Devil Hunter, Aki possesses exceptional swordsmanship, speed, reflexes, and strategy, while contracts with the Curse, Fox, Future, and Control Devils grant deadly powers, including precognition and devastating attacks

Angel Devil is a beautiful, androgynous young Devil with shoulder-length red hair, red eyes , a halo, white wings, and the Public Safety uniform. Unlike most Devils, he holds little hatred for humans and is compassionate, comforting the dying and forming a close bond with Aki. Though lazy and reluctant to fight, he avoids using his lifespan-stealing powers out of guilt. Over time, he changes from accepting death to longing for a peaceful life and protecting those he cares about. Angel absorbs human lifespans through touch, using the stolen years to forge powerful weapons, while his wings grant flight, defense, and enhanced reflexes, making him a formidable fighter despite his reluctance

Beam is a Shark Fiend with a muscular body, a shark snout replacing the upper half of his head, sharp teeth, spiky black hair, and swimming trunks. He can partially or fully transform into a massive shark with powerful fins for movement. Though eccentric, naïve, and often violent, Beam is fiercely loyal to Chainsaw Man, following Denji without hesitation and even sacrificing his own blood to revive him. He loves battle but can feel fear against overwhelming foes. As a Fiend, Beam possesses exceptional durability, can swim through solid objects, has a keen sense of smell to identify enemies, and uses his shark transformations to overwhelm opponents in close combat

Power has strawberry-blonde hair, red-and-yellow cross-shaped eyes, sharp fangs, and light red horns. She wears the Public Safety Devil Hunter uniform in a messy, half-dressed style, often using breast pads. Selfish, boastful, lazy, and dishonest, she loves fighting and avoids responsibility, yet gradually grows compassionate through her bonds with Denji, Aki, and Meowy, even risking her life for Denji. As the Blood Fiend, she manipulates blood into weapons, regenerates by consuming blood, heals others, enhances her abilities, tracks scents, and unleashes devastating attacks in her Devil form

Makima appears as a young woman with a slender build, long pale auburn hair in a loose braid, and yellow eyes with red rings that reveal her Devil nature. She wears the Public Safety uniform and maintains a calm, friendly smile that hides her true intentions. Beneath her composed facade, she is a ruthless, manipulative strategist who views others as tools and sacrifices lives without hesitation to achieve her goals. As the Control Devil, Makima can dominate humans, Devils, Fiends, animals, and Hybrids, wield their abilities, regenerate through contracts, and overwhelm enemies with immense strength, speed, intelligence, and devastating invisible attacks