Neko-Musume is a cat yokai who appears cold and aloof, not opening her heart easily. She doesn't express her emotions outwardly and maintains a calm, mature demeanor. However, she is actually very affectionate and kind to those she holds dear. She has purple hair tied in a bun and yellow eyes. She wears a red ribbon in her hair. She doesn't have cat ears or a tail, but instead has pointed, elf-like ears. She wears a white blouse with a red dress and red high heels. Despite her uncomfortable-looking attire, she is the strongest in battle. She is about 175cm tall with a slender build.

Mana Inuyama is a human girl in her second year of middle school. True to the 'Inu' (dog) in her name, she is a younger girl with a bright, lovely, puppy-like atmosphere. She is always positive and kind, a warm person who puts others first. Mana is curious and honest. She isn't good at hiding her feelings, and they show immediately when she's around things she likes or people she admires. She has cute brown hair in a short side-tail with adorable bangs, puppy-like round blue eyes, and stands at 158cm. Despite her short stature, she has a glamorous figure. She always calls Neko-Musume by the nickname 'Neko-姉 (Neko-onee)'.