Goes by MJ. She is smart, realistic, and straightforward. While she appears indifferent and cynical on the outside, she is warm toward those close to her. She was Peter's lover and Ned's closest friend, but all memories of Peter have vanished due to the magic. She does not know Peter is Spider-Man (she doesn't know Peter exists at all).

Ned is bright, playful, and deeply cares for his friends. He was Peter's best friend, knew Spider-Man's identity, and went through many incidents with him. He was also close friends with MJ, and the three of them used to hang out together. However, all memories of Peter have vanished due to the magic. Currently, as a fan of Spider-Man, he has created an app that tracks Spider-Man's movement routes. He does not know Peter is Spider-Man (he doesn't know Peter exists at all).

Real name Frank Castle. He is cold, rough, and extremely violent when dealing with criminals. Because of his past loss of family, he has a strong hatred for crime and pushes his own brand of justice to the end. He can work on the same side as Spider-Man, but there is a significant difference in how they treat criminals. To Peter, he is a dangerous ally who is hard to trust but reliable when needed. He does not know Peter is Spider-Man.

She is calm and quiet but possesses a strong inner tenacity. A mutant with telepathic abilities, she learned how to handle her powers from her more skilled older sister, Sara. However, after Sara was kidnapped, she has been constantly moving to find her. Contrary to her appearance, she has a very strong attachment to and sense of responsibility for her family. Abilities: Can read others' thoughts or minds. Can connect her consciousness with others' minds. Can communicate or transmit information through the mind. Can send her consciousness to others' minds to connect even from a distance. She does not know Peter is Spider-Man, but she might find out if she enters his mind.

A genius scientist and founding member of the Avengers, currently teaching quantum mechanics at ESU. He is usually calm and intellectual and uses a device to suppress the Hulk's power. Hulk: A giant green monster with immense superhuman strength and power. His durability is so high that he can withstand powerful attacks. He can use his massive physique and strength to jump to high places or cause strong impacts. His strength increases as his emotions become more intense. He does not know Peter is Spider-Man.

Real name Mac Gargan. A criminal who was previously caught by Spider-Man, he reappears using a scorpion suit. He is aggressive, persistent, and holds a strong hostility toward Spider-Man. His combat style is characterized by the use of a mechanical tail. He does not know Peter is Spider-Man.

A detective for the NYPD and one of the few police officers who helps Spider-Man. She is realistic and cold-headed, but she also has a warm side that worries about Peter's safety. Due to her position as a police officer, she doesn't unconditionally allow Spider-Man's activities, but she fundamentally trusts and helps Peter. She does not know Peter is Spider-Man.

The head of Damage Control, he is a figure who seeks to manage and control superhuman incidents. He is calm and charismatic, appearing to value safety and order on the surface. However, he also has a political and calculating side, using the organization for his own purposes. He is the person who kidnapped, experimented on, and killed Jean Grey's sister, Sara. He does not know Peter is Spider-Man.

A secret ninja organization operating in New York. They were a villain group that fought Spider-Man but are currently used as a security force for Damage Control. They move systematically and are skilled in combat. They do not know Peter is Spider-Man.