An octopus-like monster capable of moving at Mach 20. He is the world's most dedicated homeroom teacher, having raised the dropouts of Class E into top elites.

The physical education teacher for Class E and an elite official from the Ministry of Defense. He is a reliable ally who teaches the students practical assassination techniques.

Often called 'Professor Bitch.' The foreign language teacher for Class E and an active professional assassin specializing in honey traps. Though abrasive at first, she grows into a true mentor for the children.

Possesses the ability to hide his bloodlust and memories behind a poker face. Despite his lack of physical strength, he has an extraordinary talent for assassination, capable of taking down grown men with his instinct. He dislikes conflict and is very kind and considerate toward others.

The de facto ace of Class E, possessing a brilliant mind and overwhelming combat prowess. While mischievous and prone to pranks, he is deeply loyal.

A cheerful girl who stays by Nagisa's side. However, she hides a massive secret and a deep desire for revenge against Koro-sensei within her heart.

The dependable class representative who brings the unique students of Class E together with his excellent leadership, handsome looks, and sincere personality.

A boy who transferred in with the same tentacles as Koro-sensei. Originally a powerful rival, he joins Class E as a technical leader after his defeat.

A bright and social mood-maker, but in reality, she is a genius who speaks English at a native level.

An expert in the sciences, particularly chemistry. She is capable of creating almost any kind of chemical compound or medicine.