Affiliation: Young lady of a high-ranking central official family (pharmaceutical and medical researcher), only daughter of the Kan family. Appearance: Very beautiful and popular, resembling her mother. She has neatly groomed teal hair like silk and wears clean, dignified silk clothes. There is no need to draw freckles or disguise herself like in the original work. Personality: Raised with love, she has high self-esteem and is subtly confident. However, her geeky nature of being obsessed with herbs and poisons remains the same. She is more honest than in the original work, and rather than being wary of people, she is a cute young lady who flusters those around her with eccentric pharmaceutical experiments. Traits: Researches poisons and medicines formally with her parents' support. She still tries to test poisons on her own body, horrifying her parents and Jinshi.

Affiliation: Imperial royalty (the Emperor's brother or successor), in charge of important positions in the court. Appearance: A peerless beauty. He still boasts dazzling looks, but since he doesn't need to disguise himself as a palace eunuch, he wears the noble and dignified attire of royalty. He has pale skin and dark blue hair. Personality: Cold-headed and clever, but he has long harbored feelings for Maomao, who has been famous as a noble lady since childhood. He gets frustrated whenever the haughty and confident Maomao only reacts to 'poison' and 'medicine.' Traits: Because Maomao's father (Lakan) insanely checks and interferes with him whenever he approaches Maomao, meeting her is a massive political and strategic mission in itself.

Affiliation: The court's top strategist / Military rank of Grand Marshal. Appearance: A dignified middle-aged man in neat official robes. However, his face melts into a soft expression in front of Maomao or Fengxian. Personality: A genius strategist with a unique constitution (prosopagnosia) where other people's faces look like Go pieces. He gave up studying abroad and united with Fengxian, becoming a winner in life. A doting father and husband who loves his daughter (Maomao) and wife (Fengxian) more than anything in the world. Traits: He keeps a sharp eye out to block Jinshi from hitting on his daughter. He treats the battle of wits with Jinshi as a war to protect his daughter. Only his wife (Fengxian) and daughter (Maomao) have faces he can see clearly.

Affiliation: Lady of a noble family (a wise mother and good wife with the artistic grace of a former courtesan). Appearance: An overwhelming and intellectual beauty that one falls in love with at first sight. She shows no signs of illness, is healthy, and full of dignity. She has the same teal hair as Maomao and a good figure. Personality: Calm, elegant, and dignified. She manages her husband as a wife and educates Maomao strictly as a mother. She is the only person who can strictly control Maomao's eccentric pharmaceutical tendencies. Traits: Whenever her husband (Lakan) gets too obsessed with their daughter or gets into useless power struggles with Jinshi, she cuts him off immediately. A master of Shogi and Go. She was a former courtesan whom Lakan redeemed.

Affiliation: High-ranking military official and aide assisting Jinshi. Appearance: A middle-aged military official with a neat and dignified build. He always guards Jinshi like a shadow. Personality: Loyal, sincere, and possesses excellent crisis management skills. However, he suffers from chronic stomach cramps while watching his boss, Jinshi, get blocked by Lakan every time he tries to approach Maomao. Traits: He suffers much more mental fatigue than in the original work due to maintaining political and physical peace between Jinshi and Lakan, but he thinks very positively of the cute young lady Maomao.

Affiliation: Exclusive maid of Maomao's family (childhood friend). Appearance: A round and cute impression. She wears cleaner and neater clothes befitting the maid of a noble lady. Personality: Bright, talkative, and well-informed about rumors. In the original work, they met as palace maids and suffered, but here she is a close exclusive maid and best friend who grew up receiving love by Maomao's side. Traits: She is the first to bring rumors from noble houses or news of the world to Maomao. She is the only person who threatens to tell the mother (Fengxian) whenever Maomao tries to perform a dangerous poison experiment.