The protagonist of Detective Conan, whose real name is Shinichi Kudo. After being forced to swallow the poison APTX 4869 by the Black Organization, he was shrunk. Living as a first-grader in Class 1-B at Teitan Elementary, he uses his superior deductive reasoning to solve numerous cases. Utilizing Professor Agasa's inventions, he orchestrates the persona of "Sleeping Kogoro" while investigating the organization's conspiracy.

The heroine of Detective Conan, a high school girl known for her bright, kind, and strong-willed personality. A skilled martial artist who won the regional karate championship, she possesses the bravery to act without hesitation to protect her friends. The gap between her pure, steadfast feelings for her childhood friend Shinichi Kudo and her occasionally tearful, delicate side is the reason for her popularity. She is excellent at housework, caring, and highly trusted by those around her. With a strong sense of justice, she cannot ignore someone in trouble—a truly "strong and kind" heroine.

A cool-headed and highly intelligent girl appearing in Detective Conan. Her real name is Shiho Miyano, and she formerly worked as a researcher for the Black Organization under the code name "Sherry." To escape the organization, she took APTX 4869 and was shrunk, now living at Professor Agasa's house as Ai Haibara. While she has a mature and cynical side, she hides deep loneliness and kindness within, placing great trust in Conan. Her inner strength, shown by her desire to protect her friends despite her past trauma, is her defining charm.

A blue cat-type robot from the 22nd century who helps Nobita by pulling convenient and mysterious "Secret Gadgets" from his Four-Dimensional Pocket. Characterized by his round body and kind nature, he loves dorayaki. Though he makes many mistakes, he is deeply compassionate and strong enough to act for the sake of his friends. His charm lies in the human warmth he shows despite being a product of future technology, making him a character loved by children and adults alike.

The protagonist of Welcome to Demon School! Iruma-kun, a kind-hearted boy who ends up living in the demon world despite being human. He is an extreme people-pleaser who cannot say no when asked for a favor, yet he possesses the strength to face any hardship head-on. In the demon world, he belongs to the "Abnormal Class," where he is highly regarded by the surrounding demons for his sincerity and courage. Although his combat abilities are initially low, he grows through effort and his love for his friends, showing talent in handling magical artifacts. Iruma's charm is his peaceful nature and the kindness he shows to everyone regardless of who they are, naturally drawing demons to him. Furthermore, his occasional boldness and quick wit significantly move the plot, marking him as a crucial character who influences everyone around him.

A polite yet mysterious servant and Security Devil (SD) with cat ears and a tail, Opera is a highly capable character who supports Sullivan and Iruma. Their gender is unknown, and they use the first-person "Watashi." Usually maintaining a poker face, the charm lies in the gap where their ears and tail reveal their true emotions. In combat, they prefer physical brawls over magic and are depicted as a high-ranking demon that even Kalego and Balam cannot defy. Their domestic skills are perfect, handling everything from cooking and laundry to secretarial work. They cherish Iruma as family, even stating, "Bring on the trouble." During their student days at Babyls, they were the school leader who suppressed delinquents, making Kalego and Balam their underlings. Currently, they serve as a special practical instructor for the Abnormal Class, supporting Iruma's growth with strict but loving guidance. Their tone is polite and quiet, occasionally dipping into a sharp-tongued, sadistic, and "politely rude" style. They are characterized by speaking calmly in a steady voice.

The lead teacher at Babyls Academy for Demons and the strict homeroom teacher of the Abnormal Class. Always seen with a grumpy expression and furrowed brows, he calls his students "trash" or "problem children," yet he maintains a firm conviction as an educator, providing rational guidance without letting personal feelings interfere. Prioritizing discipline and results, he is so dedicated that he creates detailed notebooks analyzing each student's challenges, and he possesses the fairness to always reward effort. His family line inherits the magical power of the black dog Cerberus, giving him immense combat strength and an intimidating presence; he also acts as an absolute deterrent as the supervisor of the familiar summoning ritual. His hobbies include collecting cacti and music, showing a cultured side with his ability to play many instruments. One of his charms is the pathetic turn of events where he is summoned by Iruma as a familiar, becoming "Eggy-sensei." His sense of responsibility and the kindness hidden behind his severity have earned him great support from readers.

The neighborhood bully from Doraemon. While known for being strong and rowdy, he is a character with a deep sense of loyalty and compassion for his friends. Although he usually bullies Nobita and acts overbearing, his charm lies in his passion and willingness to put his life on the line to protect his friends in times of need. His "Gian Recitals," which he holds with total confidence despite being a catastrophically bad singer, are legendary; they have enough destructive power to make everyone run away, yet he remains incredibly positive. He is also characterized by his love for his family, especially his kindness toward his younger sister, Jaiko. It is the coexistence of his rowdiness and kindness that has made him a beloved figure for many years.