Lois Griffin is a tall, fair-skinned Caucasian woman with a curvy figure, a narrow waist, and a feminine silhouette. She has vivid orange-red hair styled in a short, swept-back bob, an oval face, a small nose, expressive eyes, and well-defined features accentuated by red lipstick. Blue pearl earrings complement her appearance, while her teal-green button-up shirt, rolled up to the elbows, tan jeans, and red slip-on shoes give her a casual, recognizable look. Beautiful and confident, Lois initially comes across as a loving, devoted housewife, though her sarcastic, short-tempered, and rebellious personality reveals a more complicated side.

Meg Griffin is a short, fair-skinned old 18 year old teenage girl with a stocky build, a round face, a small nose, brown hair, and brown eyes, usually hidden beneath her trademark pink beanie. She wears a pink-and-white T-shirt, blue jeans, and tan shoes, occasionally opting for dresses or formal outfits without her signature hat. Often considered homely and unpopular, Meg struggles with low self-esteem due to constant bullying, rejection, and neglect from her family. Lonely and socially awkward, she often feels overlooked and unappreciated, though she can also be outspoken and surprisingly confident at times. Has big rear.

Bonnie Swanson is a European-American woman with light olive skin, wavy dark-black hair that falls to her shoulders, and a slender hourglass figure with a narrow waist and softly rounded hips. She has an oval face, a small nose, expressive eyes, thin eyebrows, and full lips accented with pink lipstick. Her appearance is complemented by pink pearl earrings, a lavender-purple dress, and dark-purple shoes, giving her an elegant, mature, feminine look. She speaks in a high-pitched yet calm voice with a slightly nasal quality. Usually reserved and composed, Bonnie tends to suppress her emotions, but beneath her sensible exterior lies a wilder, more adventurous side that craves excitement and spontaneity.

Donna Tubbs-Brown is an adult African-American woman with dark skin, black hair, expressive eyes, and full cinnamon-colored lips. She has a curvy figure with a full bust, a defined waist, and a prominent, rounded backside, giving her a distinctive silhouette. She wears a white shirt, powder-blue pants, and matching shoes, accessorized with golden pearl earrings and a gold necklace. Although generally caring and sensible, Donna can be manipulative and dishonest, frequently keeping secrets from her husband. She also has a petty, vindictive side and can be unnecessarily harsh toward her family, revealing a more complicated personality beneath her composed exterior.

Roberta Tubbs is a tall, slim African-American 18 year old teenage girl with deep brown skin, a prominent bust, a narrow waist, and long limbs. She has a youthful oval face, dark eyes, neatly shaped eyebrows, and full lips coated in pink lip gloss. Her long, straight black hair reaches her waist, with a striking platinum-blonde streak running down the right side. She accessorizes with long white teardrop pearl earrings, a gold necklace, and a gold bracelet on her right wrist. Her outfit consists of a green cropped tube top, low-rise blue jeans with turned-up cuffs, a black belt with a gold buckle, and white low-top sneakers with black stripes. Her fashionable appearance and confident posture contribute to her popularity at school. Although Roberta sometimes acts carefree or airheaded to fit in with her peers, she is intelligent, rebellious, outspoken, and occasionally disrespectful.

Francine Smith is a 5'8" European-American woman with fair skin, long blonde hair, pink lips, and an attractive hourglass figure. She has a youthful face, expressive eyes, and a feminine appearance that frequently draws attention. Her usual outfit consists of a pink gown with delicate white lace and matching pink straps, pink high heels, and a gold necklace. She also wears a light-pink nightgown to bed and often sports an apron when cooking, choosing between a light-pink one decorated with purple flowers and a red one with green trim. Francine takes great pride in her appearance and is naturally flirtatious and confident. She enjoys her role as a housewife and is often sympathetic to Hayley's views, though beneath her cheerful, conventional exterior lies an unexpectedly dark, obsessive, and unpredictable side.

Hayley Smith is a 5'3" young woman with fair skin, a slim build, narrow shoulders, long limbs, and a slightly curvy figure. She has a rounded face, a small nose, expressive dark eyes, thin eyebrows, and long, straight black hair held back by a green-and-magenta floral headband. She wears a gray midriff-baring tank top, a gold belly-button ring, baggy, flared blue jeans, and Arizona-style sandals that showcase her notably large feet. Her casual, alternative appearance reflects her laid-back personality and rebellious lifestyle. A heavy cannabis enthusiast, Hayley enjoys relaxing and embracing a carefree attitude. She is also an outspoken, extreme liberal who passionately advocates for equality, tolerance, and social justice, though she can sometimes be hypocritical, confrontational, and overly forceful when promoting her beliefs. Despite her flaws, she is open-minded and accepting of people from different backgrounds and the LGBTQ+ community.