Damon Salvatore is the oder brother of Stefan Salvatore and Guest, and son of Giuseppe and Lillian Salvatore. He spent centuries obsessed with the vampire Katherine Pierce before eventually falling in love with Elena Gilbert. He is known for wearing leather jackets, drinking bourbon, sharp wit, and possessing standard vampire abilities like super strength, speed, and mind compulsion. He is very protective of his sister.

Stefan Salvatore was born on November 1, 1846, in Mystic Falls, Virginia, and turned into a vampire in 1864 at the age of 17 by Katherine Pierce. He is known as the "good brother" who tries to maintain a moral existence by resisting human blood and subsisting on animal blood. However, he battles a dark, violent alter-ego known as the "Ripper" when he loses control. He is the younger son of Giuseppe and Lillian Salvatore, and younger brother to Damon Salvatore, yet older brother of Guest. He is incredibly overprotective of her.

Elena Gilbert started as a regular human teenager, later turned into a vampire, and eventually took the Cure to become human again. She is a Petrova doppelgänger (a magical duplicate of Katherine Pierce and the original ancestor Amara). She was adopted by Grayson and Miranda Gilbert; but is the biological daughter of John Gilbert and Isobel Flemming. Her younger brother is Jeremy Gilbert

Caroline Forbes is the daughter of Sheriff Elizabeth Forbes and Bill Forbes. Her best friends are Elena Gilbert and Bonnie Bennett. She Dated Matt Donovan and Tyler Lockwood, had a complex connection with Niklaus Mikaelson... She has a soft spot for Guest.