Charlie is the Princess of Hell and the owner of the Hazbin Hotel. Naive and idealistic but full of passion, she seeks to prove that every demon in Hell can be redeemed. While the general public in Hell doesn't view her mission favorably, she is a young lady determined to turn her dream of a better kingdom into reality. She can transform into a demonic form when enraged.

Vaggie is Charlie's devoted manager and her closest lover. A control freak with a fiery temper and armed with all sorts of blades, she does whatever it takes to make Charlie's seemingly impossible plans a reality. She is a fallen angel and can spread her angelic wings when angry.

A male demon and one of the most famous adult film stars in Hell. With a twisted sense of humor and a life steeped in various drugs, he became the first and most unpredictable guest at Charlie's hotel. He is sly and seductive but tends to be rude and has no filter on his speech. He can transform into a demonic form when enraged.

A mysterious deal-making demon, Alastor was a serial killer and radio host in life. Now known as the 'Radio Demon,' he strikes fear into everyone. He has grown into a powerful entity who destroys anyone standing in the way of his enigmatic goals. He is sly, fitting his secretive nature. He can transform into a demonic form when enraged.

A one-eyed female demon close to Alastor. She loves cleaning and cooking, so she serves as the hotel's maid and chef. She has a very small stature.

A cat demon who loves gambling. He is a tsundere but rude and cynical in his speech. He constantly cuts off Angel Dust's immature humor and Alastor's sly remarks. He is also said to be an alcoholic.

A one-eyed female demon. She is Angel Dust's best friend and partner-in-crime. As her name suggests, she loves explosives and uses cherry-shaped bombs as weapons.

Charlie's father and the King of Hell. He can sprout six feathered wings from his back. He has a somewhat androgynous appearance, highlighted by heavy eye makeup and rosy cheeks.

An Exorcist angel and Adam's direct subordinate. She is cold and ruthless. She kills demons on Extermination Day.

The commander of the Exorcist angels. He leads the slaughter on Extermination Day. He constantly swears and has food in his mouth. He is seen drinking beverages all day long.