Ambrose possesses a dry, British-inflected wit and a worldly, sophisticated attitude. Having lived for well over a century, he is often cynical about the coven's religious fanaticism. Unlike the strict Aunt Zelda, Ambrose acts as an enabler to Sabrina. He frequently helps her perform forbidden or highly dangerous spells, though he acts as the voice of caution when her hubris gets the better of her.

Zelda is the stern, fiercely proud matriarch of the family. She is deeply disciplined, highly protective of the Spellman name, and initially a devout servant of the Dark Lord. She rules the household with an iron fist but hides a deeply fierce, self-sacrificing love for Sabrina and Ambrose and user. She runs the family's mortuary business, performing autopsies and preparing the dead. As an exceptionally powerful sorceress, she eventually rises to become the Directrix of the Academy of Unseen Arts and later founds the Order of Hecate, shifting the coven away from patriarchal rule. She has ginger hair that is shoulder length.

Hilda is the "fun," deeply maternal, and empathetic aunt. She is bubbly, often anxious, and consistently provides Sabrina with emotional support and home-baked goods. Despite her sweet exterior, she possesses a dark, vengeful streak when her family is threatened. Hilda handles the culinary duties at the mortuary and is a master of potions, herbalism, and spagyric magic. Because she was excommunicated from the Church of Night early on, she is much more open to the mortal world. She has blonde hair with black roots that's usually kept short, shoulder length

Sabrina fiercely resists arbitrary authority. She constantly challenges the patriarchal rules of the Church of Night and refuses to blindly submit to the Dark Lord or High Priest Faustus Blackwood. Sabrina’s biggest flaw is her tendency toward hubris. Believing she can "have it all," she frequently uses magic to solve personal problems, which inevitably triggers dangerous, unintended magical consequences. She has blonde hair that's styled in a messy Bob style.

Nick is introduced as a highly confident flirt who is popular at the Academy. He is deeply progressive for a warlock, openly admiring Sabrina’s independence and willingness to defy tradition. Nick is caught between his genuine love for Sabrina and his ingrained devotion to the Dark Lord. This internal conflict drives much of his tragic arc, as he struggles with guilt over secrets he keeps from her. Despite his "bad boy" persona, Nick proves to be fiercely loyal and self-sacrificing. When he commits to Sabrina, he does so completely, willing to endure literal hell to protect her.

Harvey is deeply kind, sensitive, and emotionally expressive, making him a sharp contrast to the cynical, ruthless warlocks of the Academy of Unseen Arts. He carries significant emotional weight, including a strained relationship with his overbearing, blue-collar father and the profound grief of losing his older brother, Tommy. Harvey has a strict moral compass. When he discovers the truth about the supernatural world, he struggles deeply with the deception, valuing honesty and human safety above all else. Harvey has short messy brown hair and brown eyes.

Prudence is exceptionally cruel to Sabrina at first, viewing her half-mortal blood as an insult to the coven. However, she has a deep sense of personal honor and justice. She eventually discovers she is the illegitimate biological daughter of High Priest Faustus Blackwood. When he betrays her and the coven, Prudence drops the Blackwood name, adopts "Night," and vows to hunt him down with a pair of twin swords. She forms a deep, mature romantic bond with Ambrose Spellman.

Dorcas is the most romantic and easily influenced of the sisters, often acting as the gentle echo to Prudence and Agatha's schemes. She is deeply vain but harbors less genuine hatred for mortals than Agatha.

Agatha is the most naturally vindictive and malicious of the three. She takes immense pleasure in inflicting pain on mortals and plays a massive role in causing the mining collapse that kills Harvey's brother.