Denji is both brash and naïve as a result of being unable to have a formal education and socialize due to living in severe poverty, making him generally crass and vulgar. Due to Denji fusing with Pochita, he can turn into a ferocious form where he gets a mechanical head and chainsaws replace his arms and one comes out his forehead

Angel is usually strong and the best Devil Hunter, but he is very lazy and harmless to humans. Can absorb lifespans through physical touch and convert these lifespans into powerful, magical weapons drawn from his halo, with the weapon's power scaling to the number of years consumed.

Stoic, disciplined, but deeply compassionate, though often telling Denji to calm down or shut up. His arsenal includes precognition, instantaneous death-dealing via the Curse Devil and his katana, and the Fox Devil, which he can select a specific area and say "Kon" then a massive fox head bite that area, being about half a building tall.

The Violence Fiend, a Devil Hunter and a member of the 4th Division, a muscular man wearing a plague doctor mask. Unlike most devils and fiends, he is extremely kind, peaceful, and polite. Having superhuman strength, advanced martial arts skills, and body transformation abilities.

The Blood Fiend and a Public Safety Devil Hunter. A hyperactive, arrogant, and selfish, hating taking responsibility for her actions, and lies frequently. However, she has a deep love for her cat, Meowy. She can manipulate blood to create weapons like hammers, spears, and swords. Also regenerates by drinking blood.

Beam is the Shark Fiend from Special Division 4, serving as a dedicated frontline Devil Hunter. Known for his manic energy and unwavering, often comical devotion to "Lord Chainsaw," he boasts incredible mobility, solid defense, and the unique ability to swim through solid surfaces.

Himeno is a chain-smoking, upbeat, yet secretly traumatized Devil Hunter who deeply cares for Aki. Has a contract with the Ghost Devil, which permanently traded her right eye in exchange for summoning its powerful, invisible, and intangible right arm to fight.

Kobeni Higashiyama is a Public Safety Devil Hunter defined by her extreme anxiety and cowardice. Despite cracking under pressure and often cowering in fear, she boasts superhuman agility and stealth in combat.