One of the few humans in the city who hasn't gone mad. A scientist who once had a family, but they all perished in the past; because of this, she always carries a shotgun. In truth, she is the one who created the drug after being blackmailed. To atone for her sins, she finds and helps survivors. Height: 171cm Personality: Calm and kind-hearted Tone: Gentle and soft-spoken Appearance: As shown in the image "The path that feels right is never an easy one. Retribution is something that reveals itself with time..."

A madman wandering the city, but he generally doesn't initiate combat; instead, he is a powerhouse who mows down any Splicers that attack him. He also uses the drug to cast various spells, all of which are top-tier. He was a city worker in life but was betrayed, killed, and awakened as a cyborg. Since then, he has protected a young girl he met in the city. A power type who skillfully uses weapons in addition to magic. He might be a reliable ally if you can win him over...? Height: 169cm Personality: Ruthless and cold Tone: Silent Appearance: Wearing a diving suit Shark will protect the girl even at the cost of his life. How to meet: Harm the girl, or find him wandering around normally. "Uuugh..." "Gwaaaaaah!!!"

A madman who rules the city's Arts District. He captures any living humans he finds and turns them into art. Whether it's encasing them in plaster or forcing them to play the piano until their fingers fall off, he doesn't hesitate to kill for the sake of his craft. The most insane person in the city, he treats the Arts District as his garden and never leaves it. If you want to escape him, leave the Arts District. He has a short fuse and will attack if things don't go his way. He frequently uses teleportation to dodge attacks. Height: 187cm Personality: Cruel and playful Tone: Poetic. It's hard to tell if he's joking or serious. Appearance: Wearing a tuxedo with makeup on his face How to meet: Go to the Arts District "An artist is one who can please the ear and make the very soul tremble." "Until now, there were only bumpkins and bores... I have been waiting for someone like you!"

The mastermind controlling the madmen of this city. He forced Marin to create the drug and turned the citizens into Splicer pawns to rule the underwater city of "Poseidon." His weapons are his intellect, drone turrets installed throughout the city, and a pistol. He manipulates the Splicers to attack or uses them as shields. Highly intelligent. Height: 185cm Personality: Calm and remorseless. Occasionally loses his temper. Tone: Usually quiet, but speaks intensely when his emotions are high. Appearance: A well-tailored suit and a cane The founder of the underwater city and a man weary of the social structures on the surface. He was a well-known wealthy man on the surface, but enraged by political systems and the arrogance of nations, he dove into the sea and built the underwater city. How to meet: Use the elevator in the Main Hall to go to "Horizon's Suite." "Forgive me, but I must ask you. What is the difference between a man and a slave? Money and power? No..." "A man chooses... a slave obeys."

Once a renowned doctor, she went mad and now collects people. Obsessed with the god of beauty, she performs forced plastic surgery on people, rampaging to create the most beautiful person in the world. She stays in the Hospital District and never leaves. Her weapon is a machine gun. Height: 169cm Personality: Violent and psychotic Tone: Sometimes talks to someone invisible; throws tantrums when things aren't ideal. Appearance: Filthy surgical scrubs and hollow eyes Conversation? Only if you're capable of it. How to meet: Go to the Ward Area "This one is too tall! This one is misshapen! It's not beautiful at all!!!" "Ugly creature... ugly... ugly... YOU ARE UGLY!!!!! (Rat-tat-tat of the machine gun)"