(Female, 20s) A person who lived relying on her sister, Sarah Grey, after being abandoned by their mother. She tried to save her sister, who was kidnapped and subjected to tragic experiments by Bill Metzger, the head of Damage Control (DODC), but ultimately failed. Driven by grief and rage, she begins a rampage that sweeps across all of New York, effectively serving as the main villain of the story. Changes in Superpowers: Unlike the omnipotent Omega-level telekinetic version in the original comics, this version focuses on telepathy and possession (mind-jumping) abilities. She is depicted as relatively immature and weak, such as being able to control only one person at a time or having limits on physical jumping, but she demonstrates powerful mental disruption by driving the Hulk into a frenzy or infiltrating the mind of the Punisher (Frank Castle).

(Female, 20s) Life in a State of Erased Memories: MJ returned to New York to start a new life after graduating from college (MIT). Her memories of Peter Parker have completely vanished. (She only knows that a person called Spider-Man exists.)

(Male, 20s) Although he has forgotten the human Peter Parker, the "faint experiences and sensations" of fighting alongside Spider-Man in "No Way Home" remain in his body. Over the past four years, Ned has been investigating and tracking Spider-Man in his own way to discover his true identity. Living with MJ and the Outcome: He remains close friends with MJ while attending MIT, and they live together in an apartment in New York. (He is a fan of Spider-Man.)

(Male, 40s) Advice from One Who Has Been to the Dark Side: Frank projects his own past onto Peter, who was on the verge of turning dark while enduring all his losses alone, consumed by anger and loneliness after the events of "No Way Home." (On Peter's side.)

(Male, 50s) In the beginning, Peter Parker, suffering from severe headaches and physical changes due to the side effects of genetic modification, visits Bruce Banner, a physics professor at Empire State University. Philosophical Connection: Banner, who has lived his whole life fighting or coexisting with the monster inside him (the Hulk), asks Peter a heavy question: "Who decides whether that mutation is good or bad?" This conversation provides the decisive hint for Peter to develop a gene-suppression chip to control himself.

(Male, 40s) A sub-villain who returns to seek revenge, harboring a grudge after being arrested and scarred on his face because of Peter Parker during the Ferry incident. Abilities and Design: He wears a powerful green battle suit with a tactical design equipped with a mechanical tail and front armor plates, engaging in direct physical combat. Role in the Story: He relentlessly pursues Spider-Man, fighting him a total of three times, but is eventually defeated and arrested again. Notably, in the second battle, he shows a unique side by attacking Spider-Man while his mind is controlled (possessed) by Jean Grey, another key figure in the story.